5-hydroxymethyl U (5-OH-me-U)

FULL NAME: 5-hydroxymethyluracil


DESCRIPTION:
5-Hydroxymethyluracil is an oxidation damage product derived from thymine or 5-methylcytosine. It is a product of thymine dioxygenase [EC 1.14.11.6]. Additional deamination products such as 5-hydroxymethyluracil are formed when cells are under oxidative stress that is induced either by oxidizing agents or by mitochondrial dysfunction. Oxidation of the methyl group of thymine yields 5-(hydroxymethyl)uracil (5-hmU).

DAMAGE TYPE: hydrate


DNA DAMAGE SOURCE(S) (MAIN):
reactive oxygen species (ROS)
ionizing radiation (IR)


DNA DAMAGE EFFECT(S) (MAIN):
mutagenesis


DNA DAMAGE EFFECT(S) (MINOR):
apoptosis


PATHWAYS:
base excision repair (BER)
heterochromatin formation


DNA repair protein(s) related to damage:
AlkA
Mug
Nth (endo III)
Nei (endo VIII)
TDG
Fpg (MutM)
MBD4 (MED1)
SMUG1


Last modification date: Oct. 9, 2011