O6-ethyl G (O6etG)

FULL NAME: O6-ethylguanine


DESCRIPTION:
O6-Ethylguanine (O6-EtGua) is one of about a dozen different alkylation products formed in the DNA of cells exposed to the alkylating N-nitroso carcinogen N-ethyl-N-nitrosourea (EtNU).

DAMAGE TYPE: alkylation damage


DNA DAMAGE SOURCE(S) (MAIN):
ethyl methanesulfonate (EMS)
N-ethyl-N-nitrosourea (ENU)
alkylating agents


DNA DAMAGE EFFECT(S) (MAIN):
cytotoxic


DNA DAMAGE EFFECT(S) (MINOR):
G→A transition
mutagenesis
point mutation
transition


PATHWAYS:
direct reversal (DR)


DNA repair protein(s) related to damage:
MGMT


Last modification date: Oct. 10, 2011