1-ethyl A (1etA)

FULL NAME: 1-ethyladenine


DESCRIPTION:
N1-ethyladenine (1etA), is formed by ethylating agents both in vitro and in vivo. The preference for formation in single-stranded DNA is owed to location of the N1 atom of adenine at a site usually protected by base pairing in double-stranded DNA. AlkB and its human homologs, ALKBH2 and ALKBH3, also repair 1etA residues in DNA, with the release of acetaldehyde as the repair product.

DAMAGE TYPE: alkylation damage


DNA DAMAGE SOURCE(S) (MAIN):
ethyl methanesulfonate (EMS)
N-ethyl-N-nitrosourea (ENU)
alkylating agents


DNA DAMAGE EFFECT(S) (MAIN):
cytotoxic
stalled replication fork


DNA DAMAGE EFFECT(S) (MINOR):
mutagenesis
point mutation


PATHWAYS:
direct reversal (DR)


DNA repair protein(s) related to damage:
ALKBH2
AlkB
ALKBH3


Last modification date: Sept. 2, 2011