3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)

FULL NAME: 3,N4-alpha-hydroxy-gamma-methyl-propanocytosine


DAMAGE TYPE: DNA adduct


DNA DAMAGE SOURCE(S) (MAIN):
crotonaldehyde (CRA)
lipid peroxidation (LPO)


DNA DAMAGE EFFECT(S) (MAIN):
carcinogen
cell cycle arrest
cytotoxic
DNA backbone distortion
stalled replication fork


DNA DAMAGE EFFECT(S) (MINOR):
mutagenesis


PATHWAYS:
base excision repair (BER)


DNA repair protein(s) related to damage:
Mug


Last modification date: Oct. 11, 2011