5,6-dihydro T (5,6-diH-T)

FULL NAME: 5,6-dihydrothymine


DESCRIPTION:
5,6-Dihydrothymine is one of the most important products of base damage by gamma irradiation of DNA in anoxic conditions. This modified base is unstable in the deprotection conditions used for classical synthesis of oligonucleotides. 5,6-diH-T is a pyrimidone obtained by formal addition of hydrogen across the 5,6-position of thymine.

DAMAGE TYPE: hydrate


DNA DAMAGE SOURCE(S) (MAIN):
ionizing radiation (IR)


DNA DAMAGE EFFECT(S) (MAIN):
mutagenesis


PATHWAYS:
base excision repair (BER)


DNA repair protein(s) related to damage:
NEIL2
Nei (endo VIII)
Nth (endo III)
Fpg (MutM)
NTHL1
NEIL1


Last modification date: Oct. 9, 2011