1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)

FULL NAME: 1,N2-alpha-methyl-gamma-hydroxy-propanoguanine


DAMAGE TYPE: DNA adduct


DNA DAMAGE SOURCE(S) (MAIN):
crotonaldehyde (CRA)
lipid peroxidation (LPO)


DNA DAMAGE EFFECT(S) (MAIN):
carcinogen
cytotoxic
DNA backbone distortion
stalled replication fork


DNA DAMAGE EFFECT(S) (MINOR):
mutagenesis


PATHWAYS:
nucleotide excision repair (NER)
prokaryotic (SOS) response


DNA repair protein(s) related to damage:
UvrC
UvrB


Last modification date: Oct. 17, 2011