2-hydroxy-A (2-OH-A)

FULL NAME: 2-hydroxyadenine


DESCRIPTION:
Isoguanine or 2-hydroxyladenine (2-OH-A) is a purine base that is an isomer of guanine. It is a product of oxidative damage to DNA and has been shown to cause mutation. It is also used in combination with isocytosine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA.

DAMAGE TYPE: oxidative damage


DNA DAMAGE SOURCE(S) (MAIN):
reactive oxygen species (ROS)


DNA DAMAGE EFFECT(S) (MAIN):
mutagenesis
point mutation


PATHWAYS:
base excision repair (BER)


DNA repair protein(s) related to damage:
MUTYH
MutY


Last modification date: Oct. 8, 2011