intrAstrand crosslink


DESCRIPTION:
Crosslinks in DNA occur when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink).

DAMAGE TYPE: crosslink


DNA DAMAGE SOURCE(S) (MAIN):
mitomycin C
psoralen
cisplatin
cancer chemotherapy
nitrogen mustard


DNA DAMAGE EFFECT(S) (MAIN):
cell cycle arrest
DNA backbone distortion
stalled replication fork


PATHWAYS:
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response


DNA repair protein(s) related to damage:
UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)


Last modification date: Dec. 15, 2011