intErstrand crosslinks (ICLs)

FULL NAME: interstrand crosslinks


DESCRIPTION:
Interstrand crosslinks (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing strand unwinding essential for polymerase access.

DAMAGE TYPE: crosslink


DNA DAMAGE SOURCE(S) (MAIN):
bischloroethyl nitrosourea (BCNU)
mitomycin C
psoralen
cisplatin
nitrogen mustard
cancer chemotherapy
acrolein (ACR)
crotonaldehyde (CRA)
trans-4-hydroxy-2-nonenal (HNE)


DNA DAMAGE EFFECT(S) (MAIN):
cell cycle arrest
DNA backbone distortion
mutagenesis
stalled replication fork


PATHWAYS:
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
homologous recombination (HR)
DNA replication


DNA repair protein(s) related to damage:
UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
MUS81
EME1
ERCC1
SLX4
SLX1A
SLX1B
TOP3A


Last modification date: Dec. 14, 2011